I try to find supplements that work well for a few important issue and not help one but be contraproductive for another. Supplements that worsen detox long-term, like copper or reduce acetyl-CoA like manganese might rather decrease the whole function of the energy metabolism.
I’m taking vitamin B2, B3 and hydroxocobalamin (sublingual) most of the time. Also I take magnesium regularly and try to figure out how helpful zinc is. I have low blood copper so zinc might be helpful for that.
Another issue is some form of choline. I think acetylcholine is extremely important but I don’t know how well supplementing some choline form works or if you should rather just try to improve methylation. If any choline, the form I had the best experience with was phosphatidylcholine. It seemed to be better for photosensitivity/ burning skin than choline hydrogentartrate, maybe because it binds cytosolic calcium and helps lower histamine like that. A woman with severe photosensitive skin improved from vitamin b2, hydroxocobalamin and phosphatidylcholine,… so it seemed to have benefits for her, too (-> Links) .
Other supplements I try from time to time are vitamin C, vitamin B5 and folate. And then I sometimes skip back and forth with some other stuff like vitamin D or iodine, but not that much anymore. I actually think vitamin D is not that good for me and it may lead to ‘copper dumping’.
I definitely felt that taking a b-complex didn’t work for me. I explain more in ‘Supplements’, but I think I had bad reactions to some b-vitamins like vitamin b6 or biotin, while I might need others like vitamin B12, 2 or 3. So I take b-vitamins seperately.
Also, I don’t take any activated vitamin forms anymore especially if they aren’t found in/ absorbable from foods. I often feel my symptoms changing or improving from eating and I have a very specific appetite at times. Like eating yoghurt with berries two times a day for weeks. So I think the nutrients I’m deficient in, are naturally found in foods.